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New TB Test To Detect More People Who Need DR-TB Treatment

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Medicins Sans Frontieres has sent in a request for this release to be featured in JATB, for which we thank them. It carries a powerful argument for problems associated with availability and pricing of drugs for DR (drug resistant) TB to be examined and solved, even while more efficient diagnostic tests evolve. Merely strengthening diagnostics would be like putting the cart before the horse!

Bharathi Ghanashyam

MSF report says fixing drug supply and price problems is urgent

Geneva/Johannesburg, 23 March 2011 – A promising new diagnostic test will finally help detect more people with drug-resistant tuberculosis (DR-TB), increasing the urgency to solve major problems around the pricing and supply of DR-TB medicines, according to a new report by the international medical humanitarian organisation Médecins Sans Frontières (MSF). DR-TB is on the rise, but less than 7% of 440,000 new cases each year receive
treatment, and DR-TB kills 150,000 people annually WHO.

The treatment of DR-TB relies on old antibiotics, many of which have severe side effects, ranging from constant nausea to deafness, and must be taken as complex regimens – patients must take up to 17 pills every day for up to two years. However, these are the only drugs that exist today that can tackle DR-TB. MSF’s report shows that these drugs are riddled with persistent supply and price problems that must be urgently addressed.

MSF has released a report which highlights the issues surrounding high prices and poor supply of the drugs needed to treat drug-resistant tuberculosis (DR-TB). DR-TB is on the rise and, according to the WHO, only 7% of the 440,000 new cases of DR-TB get properly diagnosed and treated. Because of the low demand, the drugs used to treat DR-TB are
old, expensive and prone to stockouts. MSF is calling for these problems to be urgently fixed, especially as a new diagnostic test currently being rolled out reduces the diagnosis time from 3 months to just 2 hours. This will diagnose more people, who will need to go on to treatment.

“Patients have been stuck in a vicious circle – not enough people are diagnosed, and drug supply problems along with high prices stand in the way of putting more people on treatment,” said Dr. Tido von Schoen-Angerer, Executive Director of MSF’s Campaign for Access to Essential Medicines. “The low demand for DR-TB drugs has made the market unattractive for producers, which is reinforcing supply and price problems.”

MSF’s report examined medicines used to treat DR-TB according to the number of suppliers, quality assurance and price, based on information obtained from the Global Drug Facility and drug manufacturers. It found that four of the recommended medicines are available from only one quality-assured source. Relying on a sole supplier whose production could be disrupted or stopped at any time always carries a risk of dangerous treatment interruption for patients. For example, supplies of the injectable drug kanamycin were disrupted during 2010, leading to a temporary global stockout.

Additionally, MSF’s report found that several DR-TB medicines are very expensive, with prices for two drugs having increased by more than 600% and one drug by more than 800% over the last decade. A 24-month DR-TB
treatment regimen can cost as much as US$9,000 for one patient – 470 times more than the $19 per patient it costs to cure standard, drug-sensitive TB.

“Now that we have a new test that can detect DR-TB in less than two hours instead of three months, we’re going to see many more people who will need reliable drug supplies to get cured,” said Dr. Jennifer Hughes of MSF in Khayelitsha, South Africa. MSF is rolling out the new test in 15 countries this year. “We need to see some immediate action to resolve these problems and improve access to DR-TB drugs so that more people are started on treatment and transmission of this disease is reduced,” said Dr. Hughes.

One way to kickstart increased production of some of these drugs is for donors to guarantee purchase volumes for several years to producers upfront. Other mechanisms such as better forecasting of the mid- to long-term needs for DR-TB drugs are also needed to help attract more producers to the market, to improve supply security and increase competition that helps brings prices down.

“We have developed a model of managing DR-TB within the community that can be scaled up to allow increased access to treatment in high HIV prevalent settings. With faster diagnosis and better treatment models of DR-TB we need to fix the supply and price issues with DR-TB drugs. We also need to see new drugs developed,” said Dr. Hughes.

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Written by JournalistsAgainstTB

April 2, 2011 at 2:19 pm

Posted in TB and Media

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